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So far tvdwal has created 15 blog entries.

Even though they are much bigger, elephants are much less likely to get cancer than mice – or humans

Way back in the last century, in 1975, Richard Peto, a young statistician at the University of Oxford drew attention to a statistical mystery. He proposed Peto's paradox — why do we humans suffer from so few cancers? At this stage, you will quite rightly point out that we get lots of cancers. One in every three of us will grow some kind of a cancer at some stage in our lives, and unfortunately, about one in every five of us will die from a cancer. But compare humans to mice. We are a lot bigger than mice, and we live a lot longer. If you work out the numbers, human cells divide about 10,000 times more often than mice cells. Whenever a cell divides, there's a chance of a mistake in the new DNA — and also, an extra chance of a cancer. And yet, both humans and mice have the same lifetime risk [...]

By | 2016-03-27T17:13:13+00:00 November 21st, 2015|Geen categorie|0 Comments

“The children with indentified mutations schould undergo ‘special screening”

Source NBC news More than 8 percent of children with cancer have unsuspected genetic mutations that could run in their families, researchers reported on Wednesday. These mutations not only put the children at risk of future cancers, but can mean their parents, brothers and sisters also have an unusually high risk, the team at St. Jude Children's Research Hospital in Memphis said. The findings might not only lead to new approaches to testing kids and their families for cancer risks, but could lead to better ways to treat them, as well, the team wrote in their report, published in the New England Journal of Medicine. The team at St. Jude and Washington University in St. Louis tested more than 1,100 children treated for cancer and found 8.5 percent of them had cancer-causing mutations in so-called germline cells, meaning they were likely to have been inherited. Forty percent of the children had no known family history of cancer. [...]

By | 2017-08-11T12:16:08+00:00 November 21st, 2015|Geen categorie|0 Comments

Antoni van Leeuwenhoek erkend als Nationaal Expertisecentrum Zeldzame Aandoeningen

11 expertisecentra van het Antoni van Leeuwenhoek zijn deze week door de minister van Volksgezondheid, Welzijn en Sport aangewezen als nationaal expertisecentrum.  Bij een nationaal  expertisecentrum kunnen  patiënten met een zeldzame aandoeningen terecht voor diagnose, multispecialistische en –disciplinaire zorg en behandeling. De elf expertisecentra van het Antoni van Leeuwenhoek bundelen kennis en kunde en ontwikkelen en coördineren onderzoek – ieder voor hun eigen tumorsoort. De expertisecentra hebben een coördinerende rol in de samenwerking  met regionale behandelcentra. Zij dragen zorg voor een optimale behandeling van patiënten, en adequate verwijzing van patiënten in binnen- en buitenland. Het Antoni van Leeuwenhoek heeft nu de volgende elf nationale expertisecentra: Centrum voor Zeldzame Huid Tumoren; Expertisecentrum voor Neuroendocriene tumoren; Sarcoom Expertise Centrum Amsterdam; Expertisecentrum voor erfelijke MDL-tumoren; Centrum voor zeldzame MDL tumoren; Expertisecentrum voor zeldzame schildklier tumoren; Expertisecentrum voor zeldzame lymfomen; Expertise centrum voor zeldzame thoracale tumoren; Expertise centrum voor zeldzame urologische tumoren; Centrum voor zeldzame hoofd-hals tumoren; Expertise centrum [...]

By | 2016-03-29T10:34:12+00:00 November 21st, 2015|Geen categorie|0 Comments

In memoriam: Fred Li, pioneer of population cancer genetics

June 18, 2015 — Frederick Pei Li, who helped inaugurate the era of cancergenetics by demonstrating that people can inherit a genetic susceptibility to develop certain malignancies, died on June 12 at the age of 75. A professor at Dana-Farber Cancer Institute (DFCI), Harvard Medical School, and Harvard T.H. Chan School of Public Health, Li laid the groundwork for today’s genetic counseling services for people with an inherited risk of cancer—and for efforts to develop cancer-prevention strategies for such individuals. In the late 1960s, Li and his colleague at the National Cancer Institute (NCI), Joseph Fraumeni, began tracking patterns of cancer in children. Together, they identified a small number of families in which the same rare cancers had arisen across multiple generations. Their research led them to describe what is now known as Li-Fraumeni syndrome, a rare but devastating condition in which people are highly prone to develop a variety of serious cancers at an early [...]

By | 2017-08-11T12:16:08+00:00 November 21st, 2015|Geen categorie|0 Comments

Toronto protocol

TORONTO – Luana Locke was eight months pregnant with her first child when she was diagnosed with breast cancer. Soon after, Locke learned that she had Li-Fraumeni syndrome, a cancer predisposition syndrome that put her at high risk of developing the disease. Having lost several family members to cancer, Locke later had her two children tested and found out they had also inherited the abnormal gene that causes Li-Fraumeni syndrome. Dim lights Embed New research led by The Hospital for Sick Children (SickKids) indicates that children and adults with inherited cancer susceptibility, like the Locke family, can benefit from a new cancer surveillance protocol that helps detect tumours early and improves overall survival. The study is published in the May 20 advance online edition of The Lancet Oncology. The study supports the use of genetic testing in at-risk individuals. It shows that close monitoring of patients who test positive for a genetic mutation can lead to early tumour detection. [...]

By | 2017-08-11T12:16:08+00:00 November 20th, 2015|Geen categorie|0 Comments
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